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Clinical Studies in Enviromental Health—EPA

Selected Studies

SOZIAL STUDY New

What is the purpose of this research study?

The purpose of this study is to understand how social factors may modify how people respond to air pollution.

Can I take part in the study?

You may be able to be in the study if you

  • Are between the ages of 18 to 33,
  • Do not smoke,
  • And are healthy.

What will I be asked to do?

  • Complete pre-study screening.
  • Complete a training session to learn about the study and study procedures.
  • Breathe clean air and air with carefully controlled amounts of pollutants during 2 2-day sessions.
  • Exercise on and off at 15-minute intervals during exposures.
  • Take part in breathing tests, including one called spirometry.
  • Have your blood pressure and heart rate monitored.
  • Have blood drawn before and after each exposure and on the follow up day.
  • Avoid certain medications, vitamins, and environmental exposures for 24-48 hours before study appointments.

How long will it take?

Following initial screening, the study will take about 18 hours over about 5-6 weeks.

What will I get for volunteering?

If you complete the procedures, we will pay you $1500.00.

How can I sign up or get more information?

Call us or send an email. Our office hours are Monday-Friday from 8am to 5pm EST. After hours, please leave a message on voice mail, and we will return your call promptly.

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GEMINOZ STUDY

What is the purpose of this research study?

Researchers from the U.S Environmental Protection Agency want to assess whether epigenetic factors in individuals with different genetic makeup make a person more or less responsive in inflammation following controlled ozone exposures.

Can I be in the study?

You may be in the study if you:

  • Are ages 18-40
  • Healthy males or females
  • A non-smoker

What will I be asked to do?

  • Answer questions about your health and how you are feeling each week
  • Do breathing tests [explanation link provided] and have blood drawn each week
  • Have your temperature, heart rate [explanation link provided] and blood pressure measured each week
  • You will also be asked NOT to take certain medications, like Vitamin C, Vitamin E, multivitamins, Naproxen, anti-inflammatory agents, and Antioxidants, for the week before and throughout the study.
  • Undergo a broncoscopy [explanation link provided] procedure
  • Undergo exposure to ozone and clean air on two separate days

Where and when is the study?

Study visits will be at the U.S. Environmental Protection Agency Human Studies Facility in Chapel Hill, NC. Study visits will be scheduled Monday-Friday between 7:00 a.m. and 5:00 p.m.

How long will it take?

The physical examination evaluation may take up to 2 hours. If the subject is eligible for the study, the individual may have up to 6 more visits to the research facility over approximately 2 months. A physical examination for bronchoscopy will be performed (approximately 2 hrs). The training day visit will require approximately 2 hours. Exposure session 1 includes 2 days with the first day lasting approximately 5 hours and the second day lasting approximately 6 hours. Subjects will report to the facility at no later than 8 AM each day. Subjects will return and repeat this two day exposure session. Exposure sessions will be separated by a minimum of two weeks.

What will I get for volunteering?

If you complete the study, we will pay you $1744.00 if all visits are completed.

How can I sign up or get more information?

You can call the Subject Recruitment office at 919-966-0604 Monday-Friday from 8 a.m. to 5 p.m. We answer the phone by saying “FEFA EPA Recruiting”. After hours, please leave a message on our voice mail system so we can call back!

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CRU-BRONCHOSCOPY

What is the purpose of this research study?

The purpose of this study is to acquire cells from both blood and lungs for further test tube studies of environmental agents.

Can I take part in the study?

You may be able to be in the study if you

  • Are between the ages of 18 to 40,
  • Do not smoke, and
  • Are healthy, OR
  • Have mild asthma and are healthy otherwise.

What will I be asked to do?

  • Have a free physical exam.
  • Take part in breathing tests.
  • Have blood drawn through a small intravenouse (IV) tube.
  • Complete a training session.
  • Undergo a bronchoscopy procedure.

How long will it take?

  • After screening there will be 1 4-hour visit, but.
  • You must stay in the local area for 48 hours after the study.

What will I get for volunteering?

If you complete the procedures, we will pay you $375.00.

How can I sign up or get more information?

Call us or send an email. Our office hours are Monday-Friday from 8am to 5pm EST. After hours, please leave a message on voice mail, and we will return your call promptly.

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ENDZONE On Hold for New Subjects

What is the purpose of this research study?

The purpose of the research study is to determine whether sequential exposure to the common air pollutants nitrogen dioxide and ozone results in greater physiological changes than exposure to either pollutant alone. Healthy, nonsmoking, physically active, adults ages 18 to 45 will be exposed in a large living room sized chamber to nitrogen dioxide, ozone, and clean air under several exposure scenarios.

Can I take part in the study?

You may be able to take part in the study if you are:

  • A healthy nonsmoker, and
  • Are between the ages of 18 and 45, and
  • Normally physically active.

What will I be asked to do?

  • Complete pre-study screening.
  • Complete a training session to learn about the study and study procedures.
  • Breathe clean air and air with carefully controlled amounts of pollutants during four 3-day sessions.
  • Exercise on and off at 15-minute intervals during exposures.
  • Take part in breathing tests, including one called spirometry.
  • Have your blood pressure and heart rate monitored.
  • Have blood drawn before and after each exposure and on the follow up day.
  • Avoid certain medications, vitamins, and environmental exposures for 24-48 hours before study appointments.

How long will it take?

Following initial screening, the study will take about 66 hours over about 8-10 weeks.

What will I get for volunteering?

If you complete the study, we will pay you $2216.00.

How can I sign up or get more information?

Call us or send and email. Our office hours are Monday-Friday from 8 am to 5 pm EST. After hours, please leave a message on voice mail, and we will return your call promptly.

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TEEN AIRE

What is the purpose of this research study?

Researchers from the UNC School of Medicine and the U.S. Environmental Protection Agency want to find out how chemicals and dusts in the air outside, also known as outdoor air pollutants, affect asthma control in teens. This study is only for kids in the Raleigh area who attend study clinics.

Can I take part in the study?

You may be able to be in the study if you

  • Have been sent a letter or invited by your doctor during a clinic visit, and
  • Are between the ages of 12 and 17, and
  • Are African American, and
  • Need to take a daily controller medicine for your asthma, and
  • Your parent or guardian agrees to participate and get you to study appointments.

What will I be asked to do?

  • Answer questions about your health and how you are feeling each week
  • Do breathing tests and have blood drawn each week
  • Have your temperature, heart rate and blood pressure measured each week
  • You will also be asked NOT to take certain medicines, like Advil, Aleve, or aspirin, or fish oil food supplements, for the week before and throughout the research study
  • Your parent or guardian will be asked to answer questions about your normal day

Where and when is the study?

Study visits well be at the Rex Hospital in the UNC Asthma and Allergy Clinic. Study visits will be scheduled on either Mondays or Thursdays between 2:30 and 5:30 pm on the same day of the week.

How long will it take?

Each study visit will last about 2 hours. You will be required to come to the clinic for a total of 6 weekly visits over 2-3 months. The first visit will be 2 weeks before the second visit, and then the rest will be a week apart.

What will I get for volunteering?

If you complete the study, we will pay you $594 -- $74 the first week, and $99 each week after, and $25 extra if you finish everything. Your parent or adult who takes you to appointments will get a $35 gift card each week.

How can I sign up or get more information?

Have your parent or guardian call us at (919) 966-0604 Monday-Friday from 8 am to 5 pm. We answer the phone by saying “FEFA, LLC EPA Recruiting”. After hours, please leave a message on voice mail so we can call back!

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5 studies displayed.

Last updated on 6/12/2014.